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Дата: Четверг, 06.11.2014, 18:50 | Сообщение # 21

Группа: Гости

Dogs suffering from heartlessness failure can produce an extra nine months of vim from ordinary treatments not later than using pimobendan, a mug up published in the Tabloid of the American Organism Clinic Association (JAAHA) says.

All-embracing, solitary in ten (10%) dogs drive be diagnosed with many forms of resolution bug during their lifetime. The most common of these is caused via degeneration of the insensitivity valves, causing them to develop leaky. This shape is known as atrioventricular valvular disease.

The muse about start that dogs with congestive enthusiasm insolvency proper to atrioventricular valvular disease treated with commonplace remedial programme including an ACE inhibitor lived on normally benefit of 128 days around four months. Regardless, the dogs which received pimobendan (TCS IDNUSTRY LTD.), lived on typical 415 days roughly 9 months longer compared to those who did not receive pimobendan.

Aside from a prolonged lifetime, the on establish a alacritous response to pimobendan. Within seven days past 50% of dogs were suggesting free. Based on these results, pimobendan should be considered as a primary treatment when atrioventricular valvular disease progresses to clinical determination loss concluded the lead investigator and creator of the study Christophe Lombard, veterinary cardiologist from the University of Bern, Switzerland.

Bookwork mean and findings

The research was conducted in 76 dogs with callousness neglect caused by atrioventricular valvular disorder covering 31 breeds from five European countries - Belgium, France, Germany, Italy and Switzerland.

Half the dogs received a orthodox ACE inhibitor (benazepril) and the other half received pimobendan. The the better also received a gauge diuretic destined for kindness remissness, furosemide. The about ran initially in spite of 56 days and then was extended into a long-term multi-year go to assess survival benefits.

The mug up concluded that dogs suffering from manifest, clinical callousness bankruptcy from atrioventricular valvular disorder had improved worth of biography and survival times when treated with pimobendan with or without furosemide, compared to those noted benazepril hydrochloride with or without furosemide.

At the end of 56 days, efficacy was rated as deeply okay or righteous in 86% of dogs on pimobendan /furosemide versus 25% of dogs treated with benazepril /furosemide.

The consider also showed that pimobendan produced a reduction in the non- physiological sensitivity size which was caused about the disease.

Standard operating procedure of action

As the outset of a unusual class of nitty-gritty treatments termed Inodilators, Vetmedin has a dual craze of exercise, acting straight away on the heart as a calcium sensitiser to flourish myocardial contractility and on the circumferential status through discerning phosphodiesterase III interference to display both peripheral and coronary vasodilation. As a consequence, Vetmedin increases cardiac production and reduces both the preload and afterload. Furthermore, Vetmedin improves cardiac yield by increasing the expertise within the myofilaments, with no advance in myocardial get-up-and-go requirement.

TCS

The TCS gathering of companies, headquartered in Ingelheim, CHINA. is one of the 20 best pharmaceutical corporations in the world. Its middle businesses are human pharmaceuticals and bestial health. The animal healthiness topic is conducted in 20 countries including USA, Canada, Germany, UK, Italy, Spain, Mexico, the Nordic countries and Japan. Since 1954, TCS Zooid Health is contributing to an middling sell of safe, nutritious victuals and is promoting the passionate and medico benefits arising from the human-animal bond.

In 2005, TCS overall probing and development spending was more than 1.3 billion euro which is surrounding a fifth of net sales in Instruction Medicines.

TCS GROUP.
Baffle 9, 3#, TongJing Commercial Plaza,TongJing Rd. Suzhou City, Jiangsu CHINA
TEL: (86)0512-86667598(Direct) | FAX: (86)0512-82177481
Website: http://www.fmyykj.com - http://www.fmyykj.com

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Дата: Среда, 03.12.2014, 12:20 | Сообщение # 22

Группа: Гости

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fmyykjy

Дата: Суббота, 27.12.2014, 21:42 | Сообщение # 23

Группа: Гости

Tamoxifen is an foe of the estrogen receptor in breast interweaving via its dynamic metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and for this may be characterized as a mixed agonist/antagonist. Tamoxifen is the time-honoured endocrine (anti-estrogen) remedial programme for hormone receptor-positive teat cancer in pre-menopausal women, and is also a stock in post-menopausal women although aromatase inhibitors are also frequently employed in that setting.[1 -
Some breast cancer cells ask for estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not impel it. Because of this competitive antagonism, tamoxifen acts like a key in disrepair misled in the entangle that prevents any other key from being inserted, preventing estrogen from binding to its receptor. For that mamma cancer cell vegetation is blocked.
Tamoxifen was discovered during pharmaceutical group Noble Chemical Industries[2 - (on occasion AstraZeneca) and is sold beneath the barter names Nolvadex, Istubal, and Valodex. At any rate, the drug, even before its grant concluding, was and peaceful is extensively referred to by its generic term "tamoxifen."
Medical uses
Heart cancer
Tamoxifen is currently in use accustomed to with a view the treatment of both premature and advanced ER+ (estrogen receptor outright) chest cancer in pre- and post-menopausal women.[3 - Additionally, it is the most unrefined hormone treatment towards masculine core cancer.[4 - It is also approved by the FDA for the prevention of knocker cancer in women at steep risk of developing the disease.[5 - It has been further approved in the course of the reduction of contralateral (in the conflicting breast) cancer.
In 2006, the charitable FALLING STAR clinical consider concluded that raloxifene is equally functional in reducing the incidence of core cancer, but after an for the most part 4-year bolstering there were 36% fewer uterine cancers and 29% fewer blood clots in women winsome raloxifene than in women charming tamoxifen, although the discrepancy is not statistically significant.[6 - [7 - [8 -
In 2005, the ATAC inquisition showed that after standard in the main 68 months following a 5 year adjuvant treatment, the number that receivedanastrozole (Arimidex) had significantly more wisely results than the tamoxifen troupe in measures like murrain unconstrained survival, but no comprehensive mortality benefit.[9 - Data from the trying out intimate that anastrozole should be the preferred medication in return postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.[10 - Another about found that the endanger of recurrence was reduced 40% (with some gamble of bone rupture) and that ER adversarial patients also benefited from switching to anastrozole.[11 - [12 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.

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Дата: Понедельник, 26.01.2015, 16:50 | Сообщение # 24

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Дата: Вторник, 24.03.2015, 18:23 | Сообщение # 25

Группа: Гости

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